Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis
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چکیده
منابع مشابه
Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis
BACKGROUND Cryptococcal meningitis (CM) is the most common form of meningitis in Africa. World Health Organization guidelines recommend 14-d amphotericin-based induction therapy; however, this is impractical for many resource-limited settings due to cost and intensive monitoring needs. A cost-effectiveness analysis was performed to guide stakeholders with respect to optimal CM treatment within ...
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BACKGROUND Although the number of infected persons receiving highly active antiretroviral therapy (HAART) in low- and middle-income countries has increased dramatically, optimal disease management is not well defined. METHODS We developed a model to compare the costs and benefits of 3 types of human immunodeficiency virus monitoring strategies: symptom-based strategies, CD4-based strategies, ...
متن کاملResponding to the evidence for improved treatment for cryptococcal meningitis in resource-limited settings.
Table. Registration status, availability and price of flucytosine and amphotericin B in 9 African countries.
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BACKGROUND In the United States, cryptococcal meningitis causes approximately 3400 hospitalizations and approximately 330 deaths annually. The US guidelines recommend treatment with amphotericin B plus flucytosine for at least 2 weeks, followed by fluconazole for a minimum of 8 weeks. Due to generic drug manufacturer monopolization, flucytosine currently costs approximately $2000 per day in the...
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1HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA 2Vaccine and Infectious Disease & Public Health Science Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA 3Departments of Global Health and Epidemiology, University of Washington, Seattle, WA 98109, USA 4 Infectious Diseases Section, AIDS Program, Yale University School of Medicin...
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ژورنال
عنوان ژورنال: PLoS Medicine
سال: 2012
ISSN: 1549-1676
DOI: 10.1371/journal.pmed.1001316